KORELASI HbA1c DAN GULA DARAH PUASA TERHADAP RASIO TG/HDL-K PASIEN DIABETES MELLITUS TIPE 2 BERETNIS JAWA

https://doi.org/10.35907/bgjk.v15i1.259

Authors

  • Yanuarita Tursinawati Universitas Muhammadiyah Semarang
  • Sakinah Qurrotul A’yun Universitas Muhammadiyah Semarang
  • Zulfachmi Wahab Universitas Muhammadiyah Semarang
  • Arum Kartikadewi Universitas Muhammadiyah Semarang

Keywords:

FPG, HbA1c, TG/HDL-C, Dyslipidemia, Diabetes Mellitus type 2

Abstract

Background : Most of the causes of death in type 2 Diabetes Mellitus (T2DM) are coronary heart disease (CHD) with dyslipidemia as one of its risk factors. The best marker for early detection of dyslipidemia is the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C). In T2DM patients, glycemic control in the form of Fasting Blood Sugar (GDP) and HbA1c can be done to avoid the risk of CHD. This study aims to identify the correlation of Hba1c and GDP with the ratio of TG/HDL-K in T2DM patients with Javanese ethnicity.Methods : This research was a cross sectional study involving 107 respondents from several health centers in Semarang City with consecutive sampling method. GDP, HbA1c, and TG/HDL-K ratio were obtained from medical records. Spearman correlation statistical test was used with a significance value of p <0.05. Results: The average HbA1c (7.86 ±1.97%), GDP (160.36± 76.82gr/dL), and the TG/HDL-K ratio (3.50± 2.22) exceeded the normal number. There was a weak significant correlation between GDP and the TG/HDL-K ratio (p=0.020; r=0.224) and there was no correlation between HbA1c and the TG/HDL-K ratio (p=0.549; r=0.059) in T2DM patients with Javanese ethnicity.Conclusion: The GDP of Javanese T2DM patients is weakly correlated with the TG/HDL-K ratio but not with HbA1c. Glycemic control is needed as an early marker of CHD risk in T2DM.

 

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References

Al Faridzi, F. Z., Amalia, Y., & Triliana, R. (2020). Peran Kendali Glukosa Terhadap Trigliserida dan High Density Lipoprotein Serum pada Pasien Diabetes Melitus Tipe 2 di Malang Raya. In Jurnal Bio Komplementer Medicine (Vol. 7, Issue 2, pp. 1–10).

American Diabetes Association. (2014). Statistics about diabetes. In National Diabetes Statistics Report.

Andaryani, N. W. R. N. (2017). Rasio kadar trigliserida-kolesterol HDL serum tinggi meningkatkan keparahan klinis penderita stroke iskemik akut. Medicina, 48(3), 211–215. https://doi.org/10.15562/medicina.v48i3.161

Arab Sarhadi, N., Fakhreddin-nejad, M., Rajabi, M., Mokarrari, S., Naghipour, E., Hooshmand, K., & Mostakhdem Hashemi, M. (2019). Evaluation of Fasting Blood Sugar and Lipid Profile in Patients with Type 1 and Type 2 Diabetes and Normoglycemic Individuals in

Gorgan, Northeastern. Journal of Clinical and Basic Research, 3(1), 6–10. https://doi.org/10.29252/jcbr.3.1.6

Arsana, P. M., Rosandi, R., Manaf, A., Budhiarta, A., & Hikmat Permana. (2019). Panduan Pengelolaan Dislipidemi di Indonesia 2019. Pb. Perkeni, 9. https://doi.org/10.1002/bit.22430

Farida, Y., & Claudia Putri. (2016). Efek Penggunaan Simvastatin Terhadap Kenaikan Gula Darah Puasa Pasien Diabetes Melitus Tipe 2. Journal of Pharmaceutical Science and Clinical Research, 01(01), 58–65. https://doi.org/10.20961/jpscr.v1i1.696

González-Chávez, A., Simental-Mendía, L. E., & Elizondo-Argueta, S. (n.d.). Elevated triglycerides/HDL-cholesterol ratio associated with insulin resistance. Cirugia y Cirujanos, 79(2), 126–131.

Hariawan, H. (2010). Kadar Adiponektin pada subyek obes dengan maupun tanpa Resistensi Insulin The Adiponection levels in obese subjects with and without Insulin Resistance. In Journal Kedokteran Yarsi (Vol. 18, Issue 1, pp. 21–28).

Josten, S., Mutmainnah, & Hardjoeno. (2006). Profil Lipid Penderita Diabetes Mellitus Tipe 2. Indonesian Journal, 13(1), 20–22.

Kementrian Kesehatan Repuiblik Indonesia. (2018). Laporan Nasional RKD2018. In Badan Penelitian dan Pengembangan Kesehatan (p. 198).

Khadke, S., Harke, S., Ghadge, A., Kulkarni, O., Bhalerao, S., Diwan, A., Pankaj, M., & Kuvalekar, A. (2015). Association of fasting plasma glucose and serum lipids in Type 2 diabetics. Indian Journal of Pharmaceutical Sciences, 77(5), 630–634. https://doi.org/10.4103/0250-474X.169033

Primadana, D. A., Pandelaki, K., & Wongkar, M. C. P. (2016). HUBUNGAN KADAR HbA1c DENGAN KADAR PROFIL LIPID PADA PASIEN KAKI DIABETES DI RSUP. PROF. DR. R. D. KANDOU MANADO. In e-CliniC (Vol. 4, Issue 1). https://doi.org/10.35790/ecl.4.1.2016.10946

Rader, D., & Hobbs, H. (2015). Disorders of Lipoprotein Metabolism. In Harrison’s pronciples of Internal Medicine (19th ed., p. 421). The McGraw-Hill Companies.

Singh, G., & Kumar, A. (2011). Relationship Among HbA1c and Lipid Profile in Punajbi type 2 Diabetic Population. Journal of Exercise Science and Physiotherapy, 7(2), 99–102.

Tursinawati, Y., Hakim, R. F., Rohmani, A., Kartikadewi, A., & Sandra, F. (2020). CAPN10 SNP-19 is associated with susceptibility of type 2 diabetes mellitus: A Javanese case-control study. Indones Biomed J, 12(2), 109–114. https://doi.org/10.18585/inabj.v12i2.984

Van Niel, R. (2003). Sistem Tanam Paksa di Jawa (S. Kartodirdjo (ed.)). PT Pustaka LP3ES Indonesia.

Vinodmahato, R., Gyawali, P., Raut, P. P., Regmi, P., Singh, K. P., Pandeya, D. R., & Gyawali, P. (2011). Association between glycaemic control and serum lipid profile in type 2 diabetic patients: Glycated haemoglobin as a dual biomarker. Biomedical Research, 22(3), 375–380.

Published

2023-09-27

How to Cite

1.
Tursinawati Y, Sakinah, Wahab Z, Kartikadewi A. KORELASI HbA1c DAN GULA DARAH PUASA TERHADAP RASIO TG/HDL-K PASIEN DIABETES MELLITUS TIPE 2 BERETNIS JAWA. BIGES JUKES [Internet]. 2023 Sep. 27 [cited 2024 Oct. 5];15(1):43-8. Available from: https://ejurnal.biges.ac.id/kesehatan/article/view/259